Aims: The culture and personality of each person rooted in family and any harm to it will make trouble for the next generation. The aim of this study was to investigate the effectiveness of Islam-based couple therapy on psychological well-being and quality of life of couples.
Materials & Methods: The present study was a semi-experimental design with pre-test, post-test, and control group. This research was carried out among 16 couples, who referred to the counseling center of Rasht city in 2017. The subjects were selected using the convenience sampling method and they were divided into two groups of experimental (N=8) and control (N=8). The research tools were a short form of quality of life questionnaire (36-SF) and personality wellbeing index of adults (PWI-A). Islam-centered couple therapy protocol included a one-hour training program (8 sessions) that for the experimental group was implemented in a workshop with power point, lecture, question, and answer. Data analysis was conducted using SPSS 22 software through a multivariate analysis of variance and independent t-tests. 
Findings: There was a significant difference between the mean scores of the post-test step of experimental and control groups in the psychological well-being variable and components of quality of life (p<0.05).
Conclusion: Islam-based couple therapy is effective in promoting the psychological well-being and quality of life of couples.