The victory of the Islamic revolution is due to the application of the liberating talent of the Shiite narrative of political Islam in providing a model of resistance against the arrogant domination of the West and the transcendental values of Western modernity against religious values in the new century. A capacity that gradually became an influential and disruptive model in the equations of the global power system. Examining the meaning of the concept of resistance, dimensions, contexts, consequences and prospects of resistance and presenting its conceptual model in the thought of the Supreme Leader as a determining component in the progress of the Islamic society and overcoming the challenges caused by the power seeking of the domination system is the subject of this research. . The researcher's intended research method is to examine Hazrat Agha's speeches in the field of resistance. The results indicate that the denial of domination, independence, multi-dimensional deterrence and the achievement of modern Islamic civilization is the outline of the concept of resistance in this study.