Purpose: This research was conducted with the purpose of 
mediating the role of self-efficacy in the relationship between 
psychological flexibility and wisdom in students.
Materials and Methods: The cross-sectional research method 
is correlational. The statistical population of this research was 
made up of all female and male students of Azad Universities 
of Tehran province in 2019-2019, from which 400 people were 
selected by staged cluster sampling method. In this research, 
the tools of wisdom (Ardelt, 2003), flexibility (Bond et al., 
2011), and self-efficacy (Sherer et al., 1982) were used, all of 
which had acceptable validity and reliability. In order to 
analyze the data, SPSS-V19 and Amos-V8.8 software were 
used. Also, in order to respond to the research hypotheses, 
structural equation modeling was used.
Findings: The research findings showed that the model has a 
good fit. The results showed that flexibility did not have a 
significant direct effect on wisdom, the relationship between 
flexibility and wisdom is directly equal (t = 1.78 and β = 0.12). 
In connection with the existence of the indirect effect of 
flexibility on the wisdom of students through self-efficacy, it 
is confirmed with 95% confidence.
Conclusion: Therefore, paying attention to the mentioned 
variables helps researchers and therapists in prevention and 
designing more appropriate treatments.