Purpose: The objective of this study was to compare the effect of 12 weeks of intense aerobic and intermittent exercise followed by 2 weeks of exercise on the expression of miR-133 and miR-29 genes in the heart of type 2 diabetic rats.
Materials and methods: 48 10-week-old male Wistar rats weighing 220 ± 20 grams were randomly divided into six groups: healthy control, diabetic control, diabetic aerobic exercise, diabetic intense intermittent exercise, diabetic aerobic bitexercise, and non-diabetic intense intermittent exercise. took (each group 8 heads). Aerobic exercise was performed for 5 sessions a week with a gradual increase in speed (18-26 m/min) and time (10-55 minutes) in the form of running on a treadmill. Intense interval training for 5 sessions of 30 minutes per week was in the form of running on a treadmill with 1-minute repetitions and 2-minute active rest between each repetition. The training period was for 12 weeks and the bit training period was for 2 weeks.
Findings: The results showed that 12 weeks of training (both aerobic and intense intermittent) caused a significant increase in the expression of miR-29 and miR-133 (P<0.05), but no significant difference was observed between the two types of aerobic and intense intermittent training (P >0.05) Also, the results showed that bitumen training for 2 weeks had no significant effect on the changes caused by training in the studied variables (P>0.05). In the case of Bitamerini, no significant difference was observed between the two types of aerobic and intense intermittent exercise for any of the variables (P>0.05).
Conclusion: It seems that with the beginning of the training period, the training adaptations created in the expression of miR29 and miR133 genes start to be lost, but it does not seem that these training adaptations are completely lost until 2 weeks of training following 12 weeks of training. . Finally, there is probably no significant difference between aerobic and non-HIIT training.