Purpose: Addiction is a common problem among people in the community as a social problem, especially among young people, which have various social, health, occupational and legal harms. In this regard, the aim of this study was investigating the relationship between parent-child conflict and feeling of loneliness as predictors for drug use in adolescents.
Materials and Methods: The research method was descriptive-correlational. The research sample consisted of 200 Abadan medical students who were selected by convenience sampling method. The research tools were tendency to use drug Scale (2001), the Adolescent Conflict with Parents Questionnaire (CBQ) (1979), and the Revised Loneliness Scale (UCLA) (1980).
Findings: Statistical analysis used for this research was correlational coefficient. The data were analyzed by using Pearson correlation coefficient and stepwise regression analysis. The results of this study indicated that parent-child conflict (r= 0.39) and feeling of loneliness (r= 0.33) had significant relationship with tendency to use drug and also the results of regression analysis showed that parent-child conflict and feeling of loneliness were sufficient predictor variables for tendency to use drug among adolescents. 
Conclusion: As a Conclusion, resolving conflicts between parents and children, as well as paying attention to adolescents' personal issues, is effective in preventing drug addiction and risky behaviors during adolescence.